The index

MaleCNS simulation connected to ViZDoom through modeled visual inputs and a fixed button readout.

Research framework comparing a MaleCNS-constrained sparse recurrent controller with rewired graphs, conventional neural networks, and other controls on simple VizDoom tasks.

Hooks a MaleCNS model up to Super Mario 64, with a local dashboard and macOS setup.

Fabric mod that runs a filtered MaleCNS graph for each fly mob, with modeled sensory inputs, motor readouts, and live neural HUDs.

Trains a MaleCNS-based model to operate a steering wheel through simulated fly limbs and connect it to CARLA.

Arrange household objects and observe flies navigating a 3D browser game.

Browser arcade game with a visible escape circuit: 6,000 MaleCNS neurons influence evasive movement alongside authored game mechanics.

MaleCNS-based game-boss experiment with a Rust neural engine, Python training environment, and Three.js viewer.

Pong controller built from a MaleCNS subgraph, with documented controls and negative results for its dopamine-inspired plasticity experiments.

MaleCNS controller connected to FightingICE through explicit sensory and action mappings, with a research ledger separating connectome structure from project-defined learning ru…

FlyWire chess experiment with a Rust/WASM LIF simulation, spike traces, and disconnection controls.

Connectome simulation connected to Craftax, with PPO training of a descending-neuron readout, baseline comparisons, and a replay viewer.

Original Chromium Dino controlled by a fixed 80-neuron MaleCNS circuit with simplified leaky tanh dynamics and a 243-parameter readout trained with the cross-entropy method (CEM).

Minecraft project with a recorded MaleCNS-based interactive demo and a release roadmap.

Godot horror prototype where a MaleCNS-derived simulation influences a fly and an external adaptive event policy.

Tic-tac-toe against a full-graph MaleCNS LIF simulation with a REINFORCE-trained descending and VNC readout, plus a fire-watch mode that classifies satellite wildfire-damage til…

A macOS desktop fly combining FlyWire spiking circuits with a MaleCNS brain-to-leg extract, modeled senses, and articulated behavior.

Linux/Hyprland desktop port of DesktopFly with a brain window and stimulation controls.

Python/GTK port of DesktopFly for GNOME on X11 and Wayland, retaining the upstream FlyWire circuit and documenting platform limitations.

Browser-based FlyWire FAFB v783 LIF simulation with food, touch, light, and temperature inputs and a live neural activity display.

Local FlyWire LIF simulation linked to a persistent 3D body, sensory controls, and recorded runs.

Browser sensorimotor loop joining a modeled compound eye and optic lobe to MaleCNS descending-neuron readouts and a simulated flying body.

MaleCNS simulation with modeled color vision, smell, taste, wind, locomotion, and an inspectable room environment.

Inspectable 3D lab with a synthetic terrarium and a separate 51-body MaleCNS giant-fiber microcircuit.

CPU arcade interface for injecting current into named MaleCNS populations while viewing the modeled voltage and spike field.

Browser artwork placing a FlyWire-based fly in a terrarium with continuous sweet-sensing input.

Frozen language model coupled to the retained MaleCNS graph through a trained readout adapter.

FlyWire LIF simulation with a natural-language interface and project-defined dopamine-learning experiments.

A MaleCNS simulation receives frames from insect videos on a virtual phone.

MaleCNS-based video-feed experiment where modeled visual and mushroom-body activity influences when the viewer advances to the next clip.

Experimental MaleCNS controller with market-chart inputs, paper trading, and optional Coinbase integration.

MaleCNS-based controller for a paper-traded NIFTY options strategy through OpenAlgo.

Ableton Live music experiments driven by simulated fly motor circuits and a small trainable musical readout.

Haiku and glyph-tracing experiment using MaleCNS simulation and mushroom-body-inspired reinforcement, with a separate reduced fallback model.

MaleCNS intervention study and Three.js visualization testing how blocking modeled mAL output changes activity in courtship-related candidate neurons.

Reproducible art experiment using MaleCNS spike vectors to control the placement, rotation, and scale of print designs.

Sparse MaleCNS reservoir experiments with terminal rendering and recording/replay.

Research code for the Shiu et al.

FlyWire whole-brain LIF implementation based on Shiu et al., with multiple simulation backends and benchmarking tools.

Anatomically detailed MuJoCo fruit-fly body, walking and flight environments, and reinforcement-learning examples.

Python framework for embodied sensorimotor experiments with a biomechanical fly, sensory interfaces, and physical environments.

PyTorch implementation of connectome-constrained models of the fly visual system, with pretrained models and analysis tutorials.

PyTorch Geometric toolkit for connectome-constrained vision models: a Drosophila eye model feeding message passing over the FlyWire v783 whole-brain graph to a Kenyon-cell readout.

Browser-based WebGPU/WASM experiment joining FlyWire brain activity, MANC nerve-cord data, and a Flybody body through explicit approximate motor mappings.

Closed-loop personal research project coupling FlyWire-based neural activity to a NeuroMechFly body, with recorded simulations and documented assumptions.

Interactive FlyWire v783 whole-brain LIF simulation with stimulus controls and activity visualization.

Drosophila larval connectome experiment linking a 1,373-neuron circuit to a MuJoCo body and a language-to-stimulus interface.

Rust LIF runtime and debugging interface for stimulating, cutting, and measuring FlyWire-derived graph activity.

CUDA and CuPy simulator targeting real-time or faster execution of the FlyWire v783 graph on a consumer NVIDIA GPU.

Experimental PyTorch MPS simulator for Apple Silicon with verified data preparation, named-cell stimulation, and 3D activity reports.

Python library exposing MaleCNS as a sparse, trainable substrate for NumPy, PyTorch, and TensorFlow while keeping source topology and modeling policies explicit.

Community research repository combining a FlyWire spiking model with NeuroMechFly/MuJoCo, sensory experiments, and an accompanying preprint.

Official male CNS project, cell-type exploration, release history, and downloads.

Source for the project website and Dimorphism Explorer.

Source and generated documentation for browsing MaleCNS v1.0 cell types, connectivity, regions, and morphology.

Derived data and analysis notebooks accompanying Berg et al., including sensorimotor flow and cell-type information.

Analysis and reproduction code accompanying the complete male visual-system connectome study.

Data, figures, notebooks, and documentation for the adult female Brain-And-Nerve-Cord connectome and its accompanying publication.

Adult female brain reconstruction, research resources, and links to exploration tools.

Neuron annotations and other data products for the FlyWire v783 release.

Versioned literature-derived neurotransmitter ground truth linked across major fly connectome datasets.

Cross-dataset cell-type matches between FAFB/FlyWire and the MaleCNS optic lobe.

Source for the FlyWire Connectome Data Explorer.

Interactive platform for exploring fly brain data, constructing executable circuits, and studying their modeled function.

Executable models of the Drosophila antenna, antennal lobe, and mushroom body for early olfactory-system experiments.

Python tools for neuron morphology analysis, visualization, transformations, and data access.

FlyWire/FAFB segmentation tools for meshes, skeletons, annotations, and connectivity queries, interoperable with NAVis.

Template brains and transforms for mapping neurons between Drosophila datasets and coordinate spaces.

Python library for effective connectivity, path finding, circuit manipulation, and differentiable models at whole-brain scale.

Prepared connectivity matrices and reproducible preprocessing for MaleCNS, BANC, FlyWire, hemibrain, and other datasets.

Python library for comparative connectomics, co-clustering, cell typing, and matching across FlyWire, hemibrain, MANC, and MaleCNS.

Unified Python interface that normalizes connectivity, metadata, and morphology queries across CAVE and neuPrint datasets.

Python and web toolkit for path finding, network visualization, morphology, and cross-dataset analysis across neuPrint, FAFB, and BANC.

Interactive application for exploring high-dimensional connectomic clusterings with linked 2D, 3D, connectivity, and annotation views.

Generates anatomical Drosophila videos from high-level descriptions using neuPrint data and Blender or VVDViewer.

R access to MaleCNS data with metadata and morphology conveniences.

Comparative connectomics across fly datasets, including FlyWire, hemibrain, MANC, FANC, and MaleCNS.

R tools for FlyWire/FAFB segmentation, meshes, annotations, and connectivity analysis.

R client for neuPrint, designed to work with the wider natverse neuroanatomy ecosystem.

R package for querying BANC metadata, connectivity, skeletons, and meshes.

Python client for querying connectivity and metadata through neuPrint.

Python client for the Connectome Annotation Versioning Engine, used to access versioned connectomic data and annotations.

Research scripts and notebooks for network statistics, motifs, connectivity, and graph structure.

Workshop materials for loading, analyzing, and visualizing major fly connectome datasets using Python and R.

Seung Lab tutorials for programmatic access to FlyWire data, meshes, and annotations.

Code examples accompanying Schlegel and Bates et al.

Dorkenwald et al., Nature (2024), the adult female brain connectome.

Schlegel et al., Nature (2024), cell annotations and comparisons across connectomes.

Lappalainen et al., Nature (2024), the research behind flyvis.

The research accompanying flybody.

FlyWire mushroom-body LIF sat at Texas Hold’em.

Full MaleCNS v1.0 playing NES Super Mario Bros with CUDA LIF dynamics, dopaminergic learning, and a live 3D web dashboard.

MaleCNS mushroom body (KC→MBON, PAM / PPL1) learns Tetris as odor-gradient navigation with the fly’s own dopamine-gated plasticity rule.

FlyWire sub-circuits as spiking networks that play games using the fly’s own dopamine update rule.

MaleCNS soma cloud plus a reduced PAM / PPL1 / PER rate model.

Kick-the-buddy toy on a live 166,700-neuron MaleCNS.

NeoForge Minecraft 1.21.1 mod that gives a mob a FlyWire-derived LIF brain (photoreceptors, descending neurons, Kenyon cells, MBON, DAN) with dopamine-gated KC→MBON learning.

MaleCNS watches Shorts, predicts watch time, “likes,” and scrolls.

Smaller mushroom-body trading lab with odor inputs, delayed dopamine, two-fly agreement, paper BTC, and a dashboard.

Browser FPS: full MaleCNS steers via DNa02 / DNp53 and fires one shot per pIP10 courtship-song bout while LC10 “sight” is open.

Hologram flies on Snap Spectacles; each runs full MaleCNS on a Mac Metal GPU while the glasses stream room senses.

Chess via a connectome LIF ply plus search.

98-cell MaleCNS circuit + a 425-parameter readout in the browser, with silence / rewire controls.

FlyWire (~139k neurons) as a live browser spiking network.

MaleCNS wired to Flappy Bird with engineered adapters and recorded gameplay.

Frozen fly-connectome reservoir that plays Clone Hero by seeing the highway.

Two-player 13-card shedding game vs a full-connectome fly sim in the browser.

Browser LIF over FlyWire (138,639 neurons, ~2.7M connections) at 60 fps with no extra dependencies.

MaleCNS / FlyWire agent playing Half-Life via LIF dynamics, a 60×60 retina, and DirectInput.

Full MaleCNS LIF plays rock-paper-scissors chess with no training: captures as small-object chase, threats as looming / giant-fiber escape.

Live MaleCNS (~165k neurons) playing Snake, with the control mapping documented instead of hidden.

Alternate Doom fly on Princeton’s FAFB-v783 (FlyWire) dataset rather than MaleCNS.

Local 3D FlyWire v783 viewer (139,255 neurons) with optional Bad Apple!!

Local Gemma agent queries FlyWire, runs small LIF subcircuits, and includes a playable Giant Fiber swatter game against the real LPLC2/LC4 escape reflex.

4,386-neuron MaleCNS visuo-motor circuit slices fruit via a fitted descending readout.

Joshua Lochner’s WebGPU MaleCNS demo: paint / stimulate 166,700 neurons and watch an articulated Three.js fly.

MaleCNS optic lobe (65.8k neurons) as a WebGPU rate model: the fly renders 1,771 column directions and the wiring becomes wing commands.

People Playground Human driven by a thresholded MaleCNS-derived LIF graph.

One cVA puff into MaleCNS (he) and FlyWire (she) at once: he lunges, she pauses.

Kevin Lin (@linguinelabs in news write-ups) pipes Bad Apple!!

Bitcoin prediction bake-off: random forest vs a fruit-fly-connectome network.

Two MaleCNS v1.0 flies race the same paper market; one applies experimental memory updates and one does not.

Male CNS LIF maps sugar GRNs → BUY, looming LC4 / LPLC2 → ESCAPE sell.

Connectome-conditioned image diffusion and simulated fly painting on MaleCNS wiring.

Music chart voted by a GPU simulation of MaleCNS v1.0 (~165k neurons) after 84 songs.

Browser MaleCNS subset (38,178 neurons, 5.1M synapses); every spike is converted to power and lights a bulb (~6.5 µW).

Ad creatives scored by a MaleCNS retina/lamina running in the browser.

Connectome-derived grooming network plus kinematic replay in a MuJoCo / FARMS fly body (Özdil et al., Nature Communications 2026).

Runnable MaleCNS v1.0 spiking network on CPU (Numba) or GPU (CuPy), with a neuron model following

Closed-loop FlyWire (139k LIF neurons in Brian2) + FlyGym / MuJoCo.

Embodied whole-CNS MaleCNS LIF in the browser (WASM) plus MuJoCo flybody and flyvis vision.

MaleCNS adjacency-masked sparse controller trained (behavior cloning, then PPO) to fly a 3D hoop course.

MaleCNS-scale connectome (165k neurons, 25.6M synapses) trained to drive a simulated street from pixels.

Native Rust MaleCNS v1.0 sim embodied in a virtual room, with a browser visualizer.

FlyWire FAFB v783 as a ~139k-unit sparse RNN trained with DAgger to drive a wheeled MuJoCo robot, vs small-world and CNN baselines.

Jin, Zhu, Zhang, Sui.

Interactive map of 481 MaleCNS descending-neuron types onto the body parts they excite or inhibit.

Pugliese et al.

Full-CNS MaleCNS fly living in a Godot 4 sandbox.

Male Adult Nerve Cord.

CPU LIF runtime, game APIs, and on-demand MaleCNS / FlyWire data (no CUDA required).